Some of the best natural health products contain glandular ingredients and many doctors have used glandulars for years with great success. Glandular organs, such as heart, aorta, and liver, have been a food source in the human diet for centuries. The consumption of glandulars is believed to provide nutritional support to the corresponding gland in the human body. Glandular therapy has alternative names such as: organotherapy, cell therapy where extracts are injected; and live cell therapy which normally uses extracts orally or intravenously.

Glandulars contain nutritional peptides, enzymes, and substances believed to be hormone precursors. Although some believe that oral consumption of dried glandulars is no different than consuming any other protein-containing food, this belief appears to be based on the fact that the stomach breaks down proteins into their constituent amino acids and that there is no benefit from consuming foods containing specific peptides. However, this belief ignores the fact that some ingested protein is not broken down into its constituent amino acids.

Evidence suggests that with oral consumption of glandular extracts, a small percentage (5-10%) of their peptides are not broken down into their constituent amino acids but are available for intact absorption in the small intestine [16-19]. A small amount of these absorbed peptides then circulate and some of them appear to assist the human body (especially for ill persons) in performing various anabolic and catabolic processes [15-19]. Howell and others have reported that the amount of enzymes that pass through the stomach is even higher (nearly 50% [20]). Howell has also reported that individuals with significant health problems have been found to have lower levels of enzymes than healthy individuals and that oral enzyme supplementation has been helpful for many such people [20]. Although this position is not universally accepted [21], a study in the Journal of Surgery showed that oral pancreatic supplementation resulted in improved enzyme and growth levels for children who had a pancreaticoduodenectomy [22]. Recent papers have suggested that bovine glandulars may be helpful for thyroid support [23], myoclonic seizures [23], and even CHARGE syndrome [24].

Some glandular extracts also contain small, safe amounts of hormones that may contribute to their possible effectiveness. The thymus gland contains thymic hormones which Schulof found may enhance immune response for people with HIV [12]. It should be noted that many substances contained within animal tissues are similar or identical to their human counterparts [1,25-27], including certain enzymes [25] and even T cell gene regions [26]. One advantage of glandulars over herbs is that raw ovine (sheep) and bovine (cow) glandulars often contain enzymes that are identical to those in the human body, while herbs rarely do.

Some research indicates that protein contained within cow’s milk appears to slow the growth of certain human toxic cells [24]; also cows do not appear to get breast cancer [28]. Thus it may be reasonable to conclude that other substances contained within or derived from bovine/ovine sources may be helpful for other human diseases.

Harrower, a pioneering researcher of oral glandulars, believed glandulars were effective because endocrine glands experienced something he referred to as “hormone hunger” [29]. Harrower wrote:

“The practical application of this idea concerns the administration of combinations of glands in presumed pluriglandular disturbances. If, for instance, in the conditions mentioned above there is a noticeable deficiency in several of the glands of internal secretion, the thyroid, ovaries and pituitary gland for instance, there may be varying degrees of hormone hunger on the part of the organs involved, and this will influence very definitely the amount of hormones that may be missing or needed by the glands to be stimulated.”

It should be noted that when Harrower used the term “hormone” this probably should be interpreted to also include nutrients, both known and unknown, including enzymes, peptides, and hormone precursors. Harrower referred to vitamins (then newly discovered) as “plant hormones” and he called hormones the “active principles obtained from certain glands” [29].

“There is a lot of controversy about the activity of glandulars given orally…It appears the effectiveness of glandulars comes in a multi-facteted way. These facets may be grouped into three basic categories: A. Hormonal; B. Enzymatic; C. Nutritive…Any gland given for therapeutic use should contain the whole nondenatured gland…The hormones are at the same strength as those found in the natural organ, except that the water has been removed leaving only the dried concentrated tissue. These hormones fall into various categories and forms: 1. Steroids; 2. Peptides; 3. Catecholamines; 4. Amino Acids; 5. Prostaglandins; 6. Nucleotides. Their hormonal factors can be broken down into two categories: A. Lipid soluble hormones; B. Water soluble amino bases and acids…The problem with steroid or prostaglandin therapy is that the medical sciences have removed them from the naturally occurring matrix which has a fine balance of steroids and prostaglandins. There is a natural law which applies in the universe and even more so in biochemistry. For every biochemical reaction or mechanism, there is an opposing ‘feedback’ mechanism. For this reason the balance must be maintained and taking glandulars are both therapeutic and very safe since this balance is maintained. It is only when the hormones are isolated and given in large doses that side effects take place, such as ulcers in steroid therapy or liver destruction in synthetic testosterone therapy. The second class of hormones is more diverse, but just as effective and important. These are the polypeptides and phyiogenic amines such as neurotransmitters and catecholamines …And the incredible thing about these peptides is that they become more active upon digestion. They are normally secreted in long chain proteins which are then broken down into endorphins which are then digested by specific proteases into the active hormones …Therefore, most of the protein is assimilated in peptide form not amino acid form. What this means is that glandulars can actually be activated by digestion” [30]. It should be noted that bovine thyroid does not itself contain substantial amounts of thyroxin which is why it is appropriate to feed the human thyroid gland. Many raw glandular preparations contain substances that can facilitate the conversion of various susbtrates into hormones.

Cooking destroys enzymes [20]. The primary difference between raw and desiccated glandulars is the enzyme content [30]. “1. Processing is very important in maintaining enzyme activity; 2. Digestion is required to activate enzymes and peptides…how are they absorbed? …they are absorbed through standard biological processes. Up to a third of your food is absorbed through the lymph system. This is basically an open portal system which permeates through the entire digestive tract allowing large molecules such as fat micelles, enzymes, and other molecules to pass into the blood stream. Other routes of absorption are active transport mechanisms such as chemotaxis…another route is immune-absorption where the protein or molecule combines with another protein and is carried in piggy back…The third category for glandular therapy is as a food…They are rich in protein and minerals and B-complex” [30]. It should be noted that when, for example, an adrenal enzyme reaches the toes basically nothing happens as the adrenal enzymes (as well as others) are specific to, in this case, the adrenal glands. Once reaching the adrenal glands, they help the adrenal glands through various anabolic and catabolic reactions.

Animal glands have been consumed since the beginning of history [31], and even now scientific studies involving them are being published [e.g. 32]. “Glandular products have been produced and used in the U.S. for over 60 years with absolutely no reports of microbial contamination or resultant illness” [33]. They are consumed in many countries, including the U.S. as food [31,33]; they may even contain substances to reverse diseases associated with Western diets [31]. Regarding glandulars, it has been reported that, “overdosing is not a concern. Even when excess amounts have been ingested, the body can easily deaminize them” [31]. A search of the literature found one report (in a letter to the editor) of a single, temporary complaint; the glandular raised thyroid hormones levels which normalized when consumption was discontinued, from using a thyroid glandular product combined with lithium, but the daily consumption (45 tablets) was in excess of any reasonable consumption (daily quantity of thyroid hormones present: 0.5mg T4 and .09mg of T3) [34].

Foot notes:

[1] Hulsey MG, Martin, RJ. The role of animals in nutritional research. Nutr Today,1993;28 (5):1993 [2] Lee R. Adrenamin. In Product Bulletins, circa 1950 [3] Lee R. Therapeutic Food Manual, Lee Foundation for Nutritional Research, Milwaukee, circa 1950;14 [4] Lee R. Brain Cytotrophin. Lee Foundation for Nutritional Research, Milwaukee, circa 1950 [5] Profiles in Nutritional Progress. Rubicon Productions, Bakersfield, 1993 [6] Cenacchi T, et al. Cognitive decline in the elderly: a double-blind placebo-controlled multicenter study on the efficacy of phosphatidylserine administration. Aging Clin Exp Res. 1993;5:123-133 [7] Dean W, Morgenthaler J, Fowkes SW. Phosphatidylserine. In Smart Drugs II: The Next Generation. Smart Publications, Petaluma (CA), 1993:75-80 [8] Thiel R. Serious Nutrition for Health Care Professionals, 2 nd ed. Center for Natural Health Research, Arroyo Grande (CA), 1996 [9] Lee R. Pneumotrophin. In Product Bulletins, circa 1950 [10] Lee R. Mammary Cytotrophin. In Product Bulletins, circa 1950 [11] Lee R. Ovary Cytotrophin. In Product Bulletins, circa 1950 [12] Lee R. Spleen Cytotrophin. In Product Bulletins, circa 1950 [13] Lee R. Thymex. In Product Bulletins, circa 1950 [14] Schulof RS, et al. Phase I/II trial of thymosin fraction 5 and thymosin alpha one on HTLV-III seropositive subjects. J of Biologic Response Modifiers,1986; 5: 429-443 [15] Neumann C. Serious Nutrition: Incorporating Clinically Effective Nutrition Into Your Practice. Source Graphics, Kelowna (B.C.), 2005 [16] Gardner M. Intestinal assimilation of intact peptides and protein from the diet – a neglected field? Cambridge Philosophical Society, Biological Reviews,1984;59: 289-331 [17] Popov I.M., et al. Cell therapy. J International Academy of Preventive Medicine,1977; 3:74-82 [18] Burns D. Accumulating scientific evidence supports glandular therapy. The Digest of Chiropractic Economics, Nov/Dec 1987: 74-79 [19] Schwartz EF. Glandular therapy. The American Chiropractor, January/February 1983:14-18 [20] Howell E. Enzyme Nutrition. Avery Publishing Group: Wayne ( New Jersey): 11-29, 1985 [21] Green S. A critique of the rationale for cancer treatment with coffee enemas and diet. JAMA, 1992; 268 (22): 3224-3227 [22] Shamberger RC, Hendron WH, Leictner AM. Long-term nutritional and metabolic consequences of pancreaticoduodenectomy in children. Surgery, 1994;115(3): 382-388 [23] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures? Medical Hypotheses, 2006; 66(5):969-974 [24] Thiel R. Thiel R. CHARGE (Hall-Hittner) Syndrome and Nutrition: A novel case report. In review, 2006 [25] McCarren M. Animals in research: researchers use animals to learn more about human diabetes. Diabetes Forecast,1993; 46 (8): 26 [26] California Institute of Technology. Large genome comparison reveals details of genomic evolution. Cancer Weekly Feb 10, 1992;6: 3 [27] Bland J. Glandular Therapy. Circa 1989 [28] Protein in cow’s milk slows growth of cancer cells in lab tests: Mammary derived growth inhibitor ( Cornell University). Cancer Weekly April 20, 1992;12:2 [29] Harrower H. Practical Organotherapy. 3rd ed. W.B. Conkey Co.: Hammond ( Indiana): 31-36, 1921 [30] Raw Glandular Therapy. ABCO Labs, Concord (CA), circa 1998 [31] Dunbar R. Foraging for nature’s balanced diet. New Scientist August 31, 1991:25-28 [32] Thiel R. Might disorders of calcium cause or contribute to myoclonic seizures? Med Hypo. 2006; 66(5):969-974 [33] DeCava JA. Glandular supplements. Nutrition News and Views 1997; 1(3):1-10 [34] Cooper N, Palmer B. Thyroid hormone in a health food capsule. New Zealand Medical Journal 1994: 231

Maria Ricci Health

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